Endocrine Abstracts

Thyroid hormones (THs) play a critical role in the regulation of growth and development in both animals and humans. They regulate metabolism primarily through actions in the brain, white fat, brown fat, skeletal muscle, liver and pancreas. Therefore, it is not surprising that since a long time scientists have been interested in measuring TH concentration in different tissues and to relate this value with possible dysfunctions. In general, TH levels are measured by immunoassay ...

Thyroid hormones (TH) of maternal origin are critical for the proper fetal development, especially during early pregnancy. Even minor changes in maternal TH circulation can lead to various adverse outcomes. Recent studies found that the metabolites of thyroxine (T4) also play an important physiological role. For example, 3,5-diiodo-L-thyronine (T2) and 3,3′-diiodo-L-thyronine (rT2) can suppress the thyroid stimulating hormone (TSH) level ...